Thursday, November 24, 2022

Music Therapy with the Tale Teller Club, the Rain Series

#taletellerclub #iservalan #therapy #rainseries #rainmusic #freemusic #youtube #healingapp

Notes on the science behind Rife therapy

Resonant_Therapy-Molecular_Biology_22by ok33

Topics ABCD1 Factor, AM-679, AR-42, Asteromycin, BAY 73-6691, Bacillus Licheniformis-NuB Factor, CEP290 Factor, CHM Factor, FL118, G-CSF Factor, HBB Factor, HU-211, IRX-4204, Indanomycin, J-147, LCA-5 Factor, LPL Factor, Methylene Blue, MT-ND4 Factor, Naphazoline Nitrate, PHA-543613, RPE65 Factor, SB-366791, SERCA2A Factor, SR-2211, Sox4-Sox11 Factors, Stampidine, Streptomyces L74-Cyclamin, Triptolide, Yohimbine, Molecular Biology, Biotechnology, Bioengineering, Genetic Therapies, Alternative Medicine, Alternative Therapies, Resonant Therapy, Therapy, Healing Remedies, Vibrational Therapies, Healing Sound, Music-Sound Frequencies Mix, Public Domain, ok33

Most of the sound frequencies used in these recordings
correspond either to the molar mass or equivalent scalar
octave of the related products.

This work is dedicated to the public domain and
may be reproduced without authorization.

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Algorithmic piano music mixed with sound frequencies.

Public Domain

* ABCD1 factor is a protein that transfers fatty acids into peroxisomes.
Defects in this gene have been identified as the underlying cause of
adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating
disorder of the nervous system.

* AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-
activating protein (FLAP). This protein is involved in the production of
cysteinyl leukotrienes which are involved in inflammation, and AM-679 has
anti-inflammatory effects in animal studies. Respiratory syncytial virus (RSV)
is an important cause of viral respiratory disease in children, and RSV
bronchiolitis has been associated with the development of asthma in childhood.
RSV spreads from the eye and nose to the human respiratory tract. Correlative
studies of humans and direct infection studies of BALB/c mice have established
the eye as a significant pathway of entry of RSV to the lung. At the same time,
RSV infection of the eye produces symptoms resembling allergic conjunctivitis.
In a BALB/c mouse eye RSV infection model AM679 markedly reduced the RSV-driven
ocular pathology as well as the synthesis of CysLTs in the eye. In addition,
AM679 decreased the production of the Th2 cell cytokine interleukin-4 but did
not increase the viral load in the eye or the lung. These results suggest that
FLAP inhibitors may be therapeutic for RSV-driven eye disease and possibly
other inflammatory eye indications.

* AR-42 is part of a class of drugs known as HDAC (histone deacetylase)
inhibitors, which are designed to block proteins that play a key role in
mediating skeletal muscle breakdown. In cancer, HDAC proteins also tend to
drive the pathways in cancer cells that lead to aggressive cancers. AR-42 is
unique among HDAC inhibitors because it appears to have beneficial effects on
muscle health and function. In cancer patients AR-42 can significantly preserve
body weight and prolong survival while simultaneously preventing the loss of
muscle and fat tissue mass and preserving the health/strength of muscle. Most
advanced cancer patients will experience significant loss of muscle mass as the
result of their cancer at some point during their treatment, a condition
clinically known as "cachexia." The condition is most common in pancreas and
gastrointestinal cancers, with up to 70 to 80 percent of patients experiencing
severe loss of muscle mass that impacts their ability to tolerate necessary
treatments. Ar-42 is also used as a treatment of meningioma and schwannoma of
the central nervous system. Meningioma and schwannoma are benign tumors that
can present in different locations within the brain and the spinal cord and may
cause substantial morbidity for those affected individuals. AR-42 has been
found to modulate several apoptosis inhibitors as well as cell survival
regulator, including Akt, Bcl-xL, Bax, Ku70 and surviving, and exert potent
antitumor activity against multiple tumor types, such as human prostate and
hepatic cancers, at least partially through PI3K/Akt pathway inhibition. AR-42
not only decreases the severity of prostatic intraepithelial neoplasia (PIN)
and completely prevents its progression to poorly differentiated carcinoma, but
also shifts tumorigenesis to a more differentiated phenotype, suppressing
absolute and relative urogenital tract weights. AR-42 significantly reduces
leukocyte counts, and prolongs survival in three separate mouse models of
B-cell malignancy without evidence of toxicity. AR-42 has also shown greater
potency and activity in solid tumors and hematological malignancies when
compared to vorinostat.

* Asteromycin is a compound found in some Actinobacteria of the genus
Streptomyces with antimycoplasma, antibiotic, acaricidal, antitumor,
antibacterial, anthelmintic, and antiviral activity.

* BAY 73-6691 is a drug developed for the treatment of Alzheimer's disease. It
was the first compound developed that acts as a phosphodiesterase inhibitor
selective for the PDE9A subtype. The PDE9A enzyme is expressed primarily in the
brain, with high concentrations in the cerebellum, neocortex, striatum, and
hippocampus, and acts to limit the cGMP-mediated signal transduction which
occurs following glutamate binding to NMDA receptors. Consequently selective
PDE9A inhibitors were predicted to prolong intracellular responses to glutamate
and enhance glutamate signalling, and since this process is known to be
involved in learning and memory, PDE9A inhibitors should have a nootropic
effect and may be useful in the treatment of Alzheimer's.

* Bacillus licheniformis NucB is effective against the biofilm that chronic
sinusitis bacteria form, a slimy protective barrier which can protect them from
sprays or antibiotics. Sinusitis symptoms include a blocked nose, nasal
discharge or congestion, recurrent headaches, loss of the sense of smell and
facial pain. When under threat, bacteria shield themselves in a slimy
protective barrier. This slimy layer, known as a biofilm, is made up of
bacteria held together by a web of extracellular DNA which adheres the bacteria
to each other and to a solid surface -in this case in the lining of the
sinuses. The biofilm protects the bacteria from attack by antibiotics and makes
it very difficult to clear them from the sinuses. When Bacillus licheniformis
want to move on, they release an enzyme which breaks down the external DNA,
breaking up the biofilm and releasing the bacteria from the web. The enzyme
NucB when added to other biofilms it quickly dissolved the slime exposing the
bacterial cells, leaving them vulnerable.

* CEP290 factor, centrosomal protein of 290 kDa plays an important role in
centrosome and cilia development. This gene is vital in the formation of the
primary cilium, a small antenna-like projections of the cell membrane that
plays an important role in the photoreceptors at the back of the retina (which
detect light and color) and in the kidney, brain, and many other organs of the
body. The discovery of the CEP290 gene has led researchers to find another gene
critical in retinal function, LCA5. Clinical trials involving gene replacement
of these two genes have started in Philadelphia, where researchers are hopeful
that Leber Congenital Amaurosis will one day be cured. Mutations in this gene
have been associated with Joubert syndrome and nephronophthisis, and recently
with a frequent form of Leber's Congenital Amaurosis, called LCA10. The
presence of antibodies against this protein is associated with several forms of

* CHM factor encodes rab escort protein 1 also known as rab proteins
geranylgeranyltransferase component A 1. Mutations in this gene are a cause of
choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked
disease is characterized by progressive dystrophy of the choroid, retinal
pigment epithelium and retina.

* FL118 is a novel camptothecin analogue that overcomes irinotecan and
topotecan resistance in human tumor xenograft models. Camptothecin, a cytotoxic
quinoline alkaloid, was first isolated from the bark of a tree used in
traditional Chinese medicine and identified as a powerful anticancer agent.
Currently the known mechanism of action for camptothecin compounds is the
ability to inhibit DNA topoisomerase 1 (Top1) activity, which thereby induces
DNA damage and cancer cell death due to the inability of cells to complete DNA
replication. However, two camptothecin analog compounds, irinotecan and
topotecan are associated with significant shortcomings. FL118 is capable of
eliminating colon and head-and-neck tumor xenografts at its maximum tolerated
dose (MTD), and even at sub-MTD levels a high percentage of human xenograft
tumors can be eliminated. FL118 selectively inhibits the expression of multiple
antiapoptotic proteins (survivin, Mcl-1, XIAP and cIAP2) from the inhibitor of
apoptosis (IAP) and Bcl-2 families, and effectively inhibits cancer cell growth
regardless of p53 status (wild type, mutant or null). Intriguingly, cancer
cells with null or mutated p53 are more sensitive to FL118 treatment than
cancer cells with wild type p53, implying that FL118 may be more effective in
treatment of advanced cancers that lose wild type p53. FL118 appears to bypass
multiple efflux pump protein-induced resistance, which may contribute to FL118
overcoming irinotecan and topotecan resistance in vivo. Mechanistically, FL118
not only inhibits the expression of survivin, Mcl-1, XIAP, cIAP2 and HdmX/Hdm4,
but also at least bypasses ABCG2 and P-pg/MDR1 resistance and possible other
efflux pump protein-induced drug resistance, which explains the favorable
toxicity and PK profile of FL118. The compound rapidly cleared in blood
circulation while accumulated in xenograft tumors.

* G-CSF or granulocyte-colony stimulating factor is a glycoprotein that
stimulates the bone marrow to produce granulocytes and stem cells and release
them into the bloodstream. Functionally, it is a cytokine and hormone, a type
of colony-stimulating factor, and is produced by a number of different tissues.
G-CSF also stimulates the survival, proliferation, differentiation, and
function of neutrophil precursors and mature neutrophils. G-CSF factor
expression may lead to significant reduction in deaths, cerebral atrophy, and
neurological deficits following ischemia. G-CSF holds a promise as a potential
treatment for brain disorders including stroke, Alzheimer's, Parkinson's, and
amyotrophic lateral sclerosis. G-CSF when given early after exposure to
radiation may improve white blood cell counts, and is stockpiled for use in
radiation incidents. G-CSF is used with certain cancer patients to accelerate
recovery from neutropenia after chemotherapy. G-CSF is also used to increase
the number of hematopoietic stem cells in donor's blood, and may also be given
to the receiver in hematopoietic stem cell transplantation.

* HBB factor, beta globin (also referred to as, hemoglobin beta, or preferably
haemoglobin subunit beta) is a globin protein, which along with alpha globin
(HBA), makes up the most common form of haemoglobin in adult humans. HBB is
involved in oxygen transport from the lung to the various peripheral tissues.
Mutations in the gene produce several variants of the proteins which are
implicated with genetic disorders such as sickle-cell disease, Heinz body
anemias, and beta thalassemia, as well as beneficial traits such as genetic
resistance to malaria.

* HU-211 is a synthetic terpene-based cannabinoid devoid of central cannabinoid
(CB1) and peripheral cannabinoid (CB2) agonist activity, thus lacking the
psychomotor responses characteristic of delta9-THC. HU-211 does exhibit the
neuroprotective, antioxidant properties of other related compounds like
cannabidiol. HU-211 also has anti-inflammatory properties derived through
inhibition of NF-kappaB and the resulting decreases in cytokines such as
TNFalfa and interleukin-6.

* IRX-4204 is a retinoid X receptor (RXR) agonist with potential antineoplastic
and anti-inflammatory activities. IRX4204 attenuates AD and prevents plaque
deposits associated with cognitive deterioration. IRX4204 also prevents
neuropathological features associated with abnormal tau processing, another
form of abnormal protein also found in a form of Parkinson's disease associated
with dementia. Because RXRs can form heterodimers with several nuclear
receptors (NRs), IRX4204 activation of RXR may result in a broad range of gene
expression depending on the effector DNA response elements activated. Rexinoid
IRX4204 may inhibit the tumor-necrosis factor (TNF)-mediated release of nitric
oxide (NO) and interleukin 6 (IL6) and may inhibit tumor cell proliferation.
This agent appears to be less toxic than RAR-selective ligands.

* Indanomycin from Streptomyces antibioticus is an active compound against Gram
positive bacteria and insects. Indanomycin is antibiotic, antibacterial
antiprotozoal, insecticidal and ionophore -binds ions reversibly. Indanomycin
posseses affinity for both mono- and divalent ions and has been reported as a
growth promotor in ruminants. Besides being an antibiotic agent, indanomycin
attacks tumours and reduces hypertension.

* J-147 was discovered based upon efficacy in multiple cell culture models of
age-associated pathologies rather than exclusively amyloid metabolism. It is an
exceptionally potent, orally active and broadly neuroprotective compound with
the ability to enhance memory in normal animals as well as to prevent memory
deficits in Alzheimer’s disease (AD) transgenic mice. The neurotrophic and
memory-enhancing activities of J147 are associated with an increase in brain
derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive
proteins, the enhancement of LTP, the preservation of synaptic protein, the
reduction of amyloid plaques, etc. Other effects noted by researchers are
increased energy metabolism, reduced brain inflammation, reduced levels of
oxidized fatty acids in the brain, and preventing the leakage of blood from the
microvessels in the brain.

* LCA5 factor lebercilin, also known as leber congenital amaurosis 5, is a
protein that in humans is encoded by the LCA5 gene. This protein is thought to
be involved in centrosomal or ciliary functions. Mutations in the LCA5 gene are
associated with Leber's congenital amaurosis.

* Lipoprotein lipase (LPL) is a member of the lipase gene family, which
includes pancreatic lipase, hepatic lipase, and endothelial lipase. LPL encodes
lipoprotein lipase, which is expressed on endothelial cells in the heart,
muscle, and adipose tissue. The primary function of this lipase is the
hydrolysis of triglycerides of circulating chylomicrons and very low density
lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell
surface is vital to the function. The apolipoprotein, APOC2, acts as a
coactivator of LPL activity in the presence of lipids on the luminal surface of
vascular endothelium (By similarity). Severe mutations that cause LPL
deficiency result in type I hyperlipoproteinemia, while less extreme mutations
in LPL are linked to many disorders of lipoprotein metabolism. Lipoprotein
lipase deficiency leads to hypertriglyceridemia (elevated levels of
triglycerides in the bloodstream). In mice, overexpression of LPL has been
shown to affect insulin response and to promote obesity. (Most expensive med in
the world - Glybera)

* Methylene blue is often used as a treatment for urinary tract infections and
other mild infections in conjunction with other treatments. Additionally, the
compound can be used to treat malaria, cancer, skin conditions including
psoriasis, Alzheimer’s disease, and cyanide as well as carbon monoxide
poisoning. It is also used as a treatment for parasites, swine flu, and
Parkinson’s disease.

* MT-ND4 or NADH-ubiquinone oxidoreductase chain 4 factor variations' are
associated with age-related macular degeneration (AMD), Leber's hereditary
optic neuropathy (LHON), mesial temporal lobe epilepsy (MTLE) and cystic
fibrosis. Leber hereditary optic neuropathy's early symptoms include blurry
vison and usually appear during the teens or early twenties. Eyesight tends to
worsen over time, eventually leading to a severe loss of sharpness (acuity) and
color vision. These problems are caused by a loss of retinal ganglion cells
-the cells that carry visual signals from the retina through the optic nerve
and into the brain.

* Naphazoline nitrate is a rapid acting sympathomimetic vasoconstrictor of
occular artierioles. It acts to decrease congestion of the conjunctiva and is
found in many over-the-counter eye drops. Naphazoline is primarily indicated in
conditions like corneal vascularity, hyperaemia, itching, nasal congestion, and
can also be given in adjunctive therapy as an alternative drug of choice in
sinusitis. It is a sympathomimetic agent with marked alpha adrenergic activity.
It is a vasoconstrictor with a rapid action in reducing swelling to mucous
membranes. It acts on alpha-receptors in the arterioles of the conjunctiva to
produce constriction, resulting in decreased congestion.

* PHA-543613 is a drug that acts as a potent and selective agonist for the
alfa7 subtype of neural nicotinic acetylcholine receptors, with a high level of
brain penetration and good oral bioavailability. It is under development as a
possible treatment for cognitive deficits in schizophrenia.

* RPE65 factor encodes the retinal pigment epithelium-specific 65 kDa protein.
The retinal pigment epithelium-specific 65 kDa protein is located in the
retinal pigment epithelium and is involved in the conversion of all-trans
retinol to 11-cis retinal during phototransduction, which is then used in
visual pigment regeneration in photoreceptor cells. Mutations in this gene have
been associated with Leber's congenital amaurosis type 2 (LCA2) and retinitis

* SB-366791 is a potent, selective and competitive vanilloid TRPV1 receptor
antagonist; antagonizes hTRPV1 receptors activated by agonists, noxious heat,
but not protons. Displays selectivity over a wide range of receptors and
systems including CB1 and CB2 receptors, voltage-gated Ca2+ channels and the
hyperpolarization-activated current. In humans, drugs acting at TRPV1 receptors
could be used to treat neuropathic pain associated with multiple sclerosis,
chemotherapy, or amputation, as well as pain associated with the inflammatory
response of damaged tissue, such as in osteoarthritis. Other use could be as a
pepper spray antidote. SB-366791 attenuates thermal hyperalgesia and mechanical
allodynia (pain from stimuli not normally painful) without affecting mechanical
hyperalgesia following surgical incision. TRPV1 blockade increases body
temperature in multiple species, including rodents and humans, suggesting that
TRPV1 is involved in body temperature maintenance. SB366791, does not block the
precise mechanism involved in temperature adaptation.

* SERCA2A or ATP2A2 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 is a
magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the
translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen.
Normal function of the heart involves proper coordination between the
contraction and relaxation of cardiomyocytes. Proper contraction and relaxation
depends on the coordinated rise and fall of Ca2+ in the cytosol of the
cardiomyocytes. The SERCA2a transporter is found in the membrane of the SR and
plays an important role in this cycle by removing cytosolic Ca2+ from the
cardiomyocyte and pumping it back into the SR during relaxation of the heart
(diastole). SERCA2a restores SR Ca2+ for the next contraction of ardiomyocytes.
SERCA2a activity declines in patients experiencing late-stage heart failure.
This leads to an above normal amount of cytosolic Ca2+ in the cardiomyocytes
during diastole. It also results in less Ca2+ remaining in the SR for the
next contraction of the heart. The altered cycling of Ca2+ in cardiomyocytes
ultimately leads to improper functioning of the heart.

* SR-2211 works directly and specifically on at least two immune cell types
directly involved in the pathogenesis of autoimmune disease. The experimental
compound targets the nuclear receptor RORgamma, a key regulator of TH17 cells,
one of a family of white blood cells that play a role in the immune system.
Identified only a decade ago, TH17 cells have been implicated in numerous
autoimmune diseases, including multiple sclerosis, rheumatoid arthritis,
inflammatory bowel disease and lupus. SR2211, blocked development of virtually
all symptoms of rheumatoid arthritis in mice within the first eight to ten days
of treatment. The mice also showed significantly reduced bone and cartilage
erosion compared to animals that did not receive treatment.

* Sox4 and Sox11 factors play a role in shaping the identity cells assume
by regulating the expression of other genes. Loud noise, trauma, infections,
plain old aging--many things can destroy hair cells, the delicate sensors of
balance and sound within the inner ear. And once these sensors are gone, that's
it; the delicate hair cells don't grow back in humans, leading to hearing loss
and problems with balance. In a recent study, when both genes were shut down,
the entire inner ear, not just the utricle, developed abnormally. In other
experiments, turning on the genes in older mice whose hair cells were fully
matured, the activation of these genes induced the production of new hair cells
within a fully developed utricle. These genes, or others in the same pathway,
could be promising targets for efforts to treat hearing loss or balance
problems by regenerating hair cells, researchers suggest.

* Stampidine is an experimental nucleoside reverse transcriptase inhibitor
(NRTI) with anti-HIV activity. Stampidine displays remarkable in vitro and in
vivo anti-HIV activity against drug-sensitive and drug-resistant HIV strains.
Stampidine is non-cytotoxic and nonirritating to mucosal epithelial cells.
Several preclinical studies conducted thus far, suggest that stampidine has
clinical potential as a dual-function topical agent for the prevention and/or
effective treatment of oculo-genital ADV/HIV infections. Adenoviruses (ADVs)
are causative agents of severe and extremely contagious ocular and genital
infections associated with conjunctivitis, genital ulcers and urethritis.

* Streptomyces L74-Cyclamin (saponin) is an algicide compound from Triterpenoid
saponin is a type of saponin found in many plants. These compounds exhibit
antimicrobial, antibacterial, antifungal, antiviral, antiyeast, and cytotoxic
activities. In contrast to the structures of known triterpenoid saponins, this
triterpenoid saponin may be a new type of saponin from actinobacteria.
Streptomyces L74 shows two patterns of algicidal activities against M.
aeruginosa, A. flos-aquae, O. animalis, and Aph. flos-aquae. Streptomyces L74
indirectly attacks M. aeruginosa, O. animalis, and Aph. flos-aquae by using the
active substances. Streptomyces L74 directly attacks A. flos-aquae by
cell-to-cell contact. This species also exhibits high algicidal activities
against other harmful types of cyanobacteria. Eutrophic fresh water
cyanobacteria produce neurotoxins and peptide hepatotoxins, such as microcystin
and cyanopeptolin. The growth of cyanobacterial harmful algal blooms
(cyanoHABs) has become a global concern as they threaten the environment,
economy, and human health and require treatment to control pollution.

* Triptolide is a diterpenoid triepoxide found in the Thunder God Vine,
Tripterygium wilfordii. It has in vitro and in vivo activities against mouse
models of polycystic kidney disease and pancreatic cancer. It is used in
traditional Chinese medicine for treatment of fever, chills, edema and
carbuncle. Triptolide has multiple pharmacological activities including
anti-inflammatory, immune modulation, antiproliferative and proapoptotic
activity. It is also under investigation for its apparent antifertility
effects, which it is speculated, may provide a basis for a male oral
contraceptive. The mechanism by which they affect fertility is not yet
understood. What is known is that daily doses of these compounds reduce sperm
counts and also severely affect the formation and maturation of sperm, causing
them to be immotile, while stopping treatment reverses the process.

* Yohimbine is a chemical derived from the bark of the yohimbe tree, a tall
evergreen native to Western Africa. Yohimbine is a common ingredient in energy
drinks and sports nutrition supplements. It is a vasodilator, which means that
it expands blood vessels. This allows for easier blood flow and superior
circulation. In particular, studies have shown that yohimbine is effective in
improving blood flow to extremities. Lower doses of yohimbine can also lower
blood pressure and increase heart rate, which can help your body deliver
nutrients to working cells. Yohimbine is also a popular ingredient in
weight-loss and fat-burning products. This is because some studies have shown
yohimbine to be effective in removing "stubborn fat" -slimming down problem
spots like the abdomen and thighs. Yohimbine's slimming effect is due to its
blockage of alpha2 andrenoreceptors, which prevent the release of a
fat-mobilizing hormone, norepinephrine. Yohimbine ensures higher norepinephrine
levels, which causes the body to break down fat cells. This also increases
blood flow to fat tissue, which causes less fat to be retained. Yohimbine
reduces carbohydrate and fat intake, but not protein intake. This assists in
appetite suppression because protein increases feelings of fullness. The body
also burns more calories digesting protein than it does digesting carbohydrates
or fat. Supplements that promise to optimize sexual health and battle erectile
dysfunction also contain yohimbine. This is because of yohimbine's tendency to
increase blood flow to extremities -in this case, the genitals. In addition,
yohimbine can slightly increase testosterone levels in men. Women can benefit
from yohimbine as well, as the chemical can increase feelings of sexual arousal.

Algorithmic piano music mixed with sound frequencies.

Public Domain